- Wellcome Trust Doctoral Programme in Neuroscience
My research focuses on understanding the pathologic mechanisms underlying epilepsy in order to identify novel curative strategies. At the moment, approximately 1 in 100 people in the UK suffer from epilepsy and a significant number of these patients do not respond to medication.
At one level, epilepsy can be considered as a loss in the balance of synaptic excitation and inhibition in networks of the brain. I am therefore investigating ways to restore this balance, by selectively controlling the activity of specific neuronal populations in a manner that mitigates the initiation and spread of epileptic events. I adopt a targeted approach by combining genetic, optical, viral and pharmacological techniques.
This could strongly impact the way we understand epilepsy as a neurological disease and the manner in which we intervene for the management of epileptic patients.
Burst-Suppression Ratio on Electrocorticography Depends on Interelectrode Distance.
Moldovan M. et al, (2016), J Clin Neurophysiol, 33, 127 - 132
Fronto-parietal connectivity changes following noxious stimulation during anesthesia.
Pavel B. et al, (2014), J Med Life, 7, 387 - 390
Intraoperative somatosensory evoked potential monitoring decreases EEG burst suppression ratio during deep general anesthesia.
Călin A. et al, (2014), J Clin Neurophysiol, 31, 133 - 137
Peripheral motor axons of SOD1(G127X) mutant mice are susceptible to activity-dependent degeneration.
Alvarez S. et al, (2013), Neuroscience, 241, 239 - 249