MA PhD FRS FMedSci
Statutory Professor of Pharmacology
- Wellcome Trust Senior Investigator
- Professorial Fellow of Lady Margaret Hall
- Extraordinary Lecturer in Biochemical Pharmacology, New College
I was educated at Trinity College, Cambridge, and received a BA in Natural Sciences (pharmacology part 2) in 1985 and my PhD (zoology) in 1989, having worked on the role of calcium oscillations in cell activation in Sir Michael Berridge's laboratory.
After a short spell at UCL working on mammalian fertilisation with Michael Whitaker, I went to Johns Hopkins University as a Harkness Fellow studying the role of calcium signals in early development. Returning to the UK in 1991, I joined the Department of Pharmacology. I have been successively a Beit Memorial Fellow, Wellcome Trust Career Development Fellow and Wellcome Trust Senior Fellow in Basic Biomedical Research.
I was elected to a Tutorial Fellowship at New College in 1998 in conjunction with a proleptic University appointment, appointed to a titular Professor of Pharmacology in 2002, and elected to the Professorship of Pharmacology and a Professorial Fellowship at LMH in 2006. I was Head of the Department of Pharmacology from 2006-2015.
I received the 2001 Novartis Prize of the British Pharmacological Society for my scientific contributions to pharmacology. I became a Fellow of the Academy of Medical Sciences in 2010 for my contributions to the advancement of medical science, and in 2016 I was elected a Fellow of The Royal Society for my work on calcium signalling.
Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling.
Foster WJ. et al, (2018), Sci Signal, 11
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.
Aston D. et al, (2017), Sci Rep, 7
Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.
Wang Y. et al, (2017), Sci Rep, 7
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Fineran P. et al, (2016), Wellcome Open Res, 1
Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Rodrigues T. et al, (2016), Angew Chem Int Ed Engl, 55, 11077 - 11081