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- Akerman Group Research Group
Colin J Akerman
Professor of Neuroscience
- Group Leader, Department of Pharmacology
- Corange Fellow and Tutor in Medicine, Corpus Christi College
I lead a neuroscience research group within the Department of Pharmacology at Oxford University. Our work is focused on understanding general principles by which synaptic connections in the brain are formed and are altered by activity-dependent processes. This is a fundamental challenge if we are to understand how the brain is organised and how it can change in response to information received from the environment. As well as probing these basic mechanisms, the aim is to contribute to a more complete description of how synaptic circuits become altered in conditions such as epilepsy and dementia.
In order to study synapse formation and synaptic plasticity, our research combines advanced optical methods, electrophysiological recordings, molecular-genetic techniques and computational approaches. We apply these to a variety of experimental questions in vivo, in vitro and in silico. This often requires us to build and customize our own equipment, write software for the acquisition and analysis of data and develop new molecular tools for observing and manipulating neuronal activity. This integrative approach enables us to address novel biological questions, to make significant contributions in the field, and to offer a rich training environment for scientists. Please take a look at our publications to get a sense of what we are working on.
The research group began in 2008 and is now made up of approximately 10 scientists, roughly half of whom are postdoctoral scientists, and half of whom are PhD students. I have been very lucky to have worked with some excellent young scientists in the group and I am delighted that many of them have moved on to set up their own research groups in Toronto, Edinburgh, Cape Town, Oxford and London.
In addition to my role as a group leader, I am also a University Lecturer and Medical Tutor at Corpus Christi College.
Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.
Wright R. et al, (2017), J Neurosci, 37, 5447 - 5462
Mapping neurogenesis onset in the optic tectum of Xenopus laevis.
Herrgen L. and Akerman CJ., (2016), Dev Neurobiol, 76, 1328 - 1341
Random synaptic feedback weights support error backpropagation for deep learning.
Lillicrap TP. et al, (2016), Nat Commun, 7
Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors.
Raimondo JV. et al, (2016), J Neurosci, 36, 7002 - 7013
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.
Handel AE. et al, (2016), Hum Mol Genet, 25, 989 - 1000
Sensory-Evoked Spiking Behavior Emerges via an Experience-Dependent Plasticity Mechanism.
van Rheede JJ. et al, (2015), Neuron, 87, 1050 - 1062
Ion dynamics during seizures.
Raimondo JV. et al, (2015), Front Cell Neurosci, 9
Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain.
Herrgen L. et al, (2014), Dev Cell, 31, 599 - 613