Research groups
Colleges
Daniel C Anthony
Professor of Experimental Neuropathology
- Fellow of Somerville College
- Honorary Professor, University of Southern Denmark
- Fellow of the British Pharmacological Society
Daniel Anthony, a specialist in inflammatory disease, leads the Experimental Neuropathology Laboratory at the University of Oxford. As a Fellow of Somerville College and an Honorary Professor at the University of Southern Denmark, he has developed a niche in understanding how systemic inflammation influences the outcomes of both acute and chronic brain injuries and infections. His research interests also focus on the role of circulating extracellular vesicles in the pathogenesis of CNS diseases and the contribution of cytokine production to neuropsychiatric disorders.
Professor Anthony's career began with a Ph.D. from University College London in 1994, after which he joined Professor Hugh Perry in Oxford on a British Biotech Fellowship to explore metalloproteinase expression in the CNS. His work has led to the identification of novel biomarkers for diagnosing disease and predicting progression, leveraging a combination of in vivo biology, molecular biology, immunohistochemistry, MRI and PET imaging, and metabolomics. After a stint at the University of Southampton, where he was a Lecturer in Neurobiology, he returned to Oxford in 2004, where he continues to explore the neurobiology of inflammation with research collaborations throughout the world. In 2015, he was awarded a personal Chair in Experimental Neuropathology, and he was made a Fellow of the British Pharmacological Society in 2020.
Key publications
YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis
Preprint
De'Ath C. et al, (2026)
Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.
Journal article
de Almeida Miranda D. et al, (2026), Hippocampus, 36
Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.
Journal article
Kacerova T. et al, (2026), Commun Med (Lond)
The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA.
Journal article
Whitfield HL. et al, (2026), Nat Commun
TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.
Journal article
Weiden E-M. et al, (2026), EMBO J
A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets
Preprint
Tourigny K. et al, (2026)
Brain-Directed AAV Gene Therapy Rescues a Mouse Model of the CLN5 Form of Neuronal Ceroid Lipofuscinosis Disease and Normalizes a Blood Plasma Biomarker of Neurodegeneration.
Journal article
Liu W. et al, (2026), Hum Gene Ther
Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials.
Journal article
Griffiths CA. et al, (2026), Nat Biotechnol, 44, 316 - 325
Miglustat as a Treatment for Adults with Tangier Disease Neuropathy: The MUSTANG N-of-1 Trial with 21 months Clinical Observation.
Journal article
Cook A. et al, (2026), Neurol Ther, 15, 447 - 456
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence.
Journal article
Vu H. et al, (2026), JHEP Rep, 8
Links between COVID-19, long COVID, and neurodegeneration: The role of glycosphingolipids.
Journal article
Spedding M. et al, (2026), Pharmacol Rev, 78
Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.
Journal article
Ahmad M. et al, (2026), Angew Chem Int Ed Engl, 65
Molecular and biochemical insights into dysregulation of glycosphingolipid metabolism in a mouse model of lysosomal free sialic acid storage disorder.
Journal article
Sabir MS. et al, (2026), Exp Neurol, 399
Integrating NMR Metabolomics and Glycomics for Early Cancer Detection in Patients with Non-Specific Symptoms
Preprint
Kacerova T. et al, (2026)
Proton-selective conductance and gating of the lysosomal cation channel TMEM175.
Journal article
Schulze T. et al, (2026), Proc Natl Acad Sci U S A, 123
Curing the brain: In search for new astrocyte-specific therapies
Journal article
Verkhratsky A. et al, (2026), Experimental and Molecular Medicine
Mapping Vibronic Dynamics of Ultrafast Intersystem Crossing in an Earth-Abundant Ligand-Field Excited Complex.
Journal article
Yang J. et al, (2026), J Am Chem Soc, 148, 1977 - 1988
Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.
Journal article
Fu X. et al, (2026), Nat Chem
Vigilance state dissociation induced by 5-MeO-DMT in mice.
Journal article
Bréant BJB. et al, (2026), Commun Biol, 9
The Power of Diversity in Neuroscience Research Models.
Journal article
Banerjee A. et al, (2026), Eur J Neurosci, 63
Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.
Journal article
Yi G. et al, (2026), Nat Chem Biol, 22, 69 - 76
Lesion level and severity acutely influence metabolomic profiles in spinal cord injury.
Journal article
Yates AG. et al, (2026), J Neuropathol Exp Neurol, 85, 24 - 38
Stephen Ashcroft, 27 January 1942-28 November 2025 IN MEMORIAM
Journal article
Ashcroft F. et al, (2026), DIABETOLOGIA
Cognition-enhancing and neuroprotective potential of steroid sulfatase inhibitors Irosustat and STX140 in a scopolamine-induced Alzheimer's disease rat model
Conference paper
Anbar H. et al, (2026), BRITISH JOURNAL OF PHARMACOLOGY, 183
Limited therapeutic efficacy of N-acetyl-L-leucine in a mouse model of CLN1 disease.
Journal article
Ziółkowska EA. et al, (2025), Sci Rep, 16
Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts.
Journal article
Ye M. et al, (2025), ACS Cent Sci, 11, 2385 - 2399
Pathological tau alters head direction signaling and induces spatial disorientation.
Journal article
Jiang S. et al, (2025), Cell Rep, 44
The effects of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain
Preprint
Radford-Smith D. et al, (2025)
Unrevealing the role of hypothalamic corticotropin-releasing hormone neurons in blood pressure regulation in hypertension.
Journal article
Zhang H. et al, (2025), Cardiovasc Res, 121, 2565 - 2577
Evaluating the risk of atrial fibrillation in patients with chronic recurrent pericarditis prescribed colchicine: Observations using TriNetX global federated research network.
Journal article
Kaşkal M. et al, (2025), Eur J Clin Pharmacol, 82
Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis.
Journal article
Sereesongsaeng N. et al, (2025), Elife, 14
A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis.
Journal article
Whitfield HL. et al, (2025), Biochem J, 482, 1815 - 1830
Calcium activated chloride channel (CaCC) in GtoPdb v.2025.4
Journal article
Danahay H. et al, (2025), IUPHAR/BPS Guide to Pharmacology CITE, 2025
Protocol for endolysosomal proteomics in goat atrial tissue using a refined density-gradient approach.
Journal article
Ayagama T. et al, (2025), STAR Protoc, 6
Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.
Journal article
Rao R. et al, (2025), Trends Cogn Sci
N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation
Preprint
Davis LC. et al, (2025)
Structural electrobiology: architecture of the bioelectric code.
Journal article
Beaudoin CA. et al, (2025), Open Biol, 15
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels.
Journal article
Alexander SPH. et al, (2025), Br J Pharmacol, 182 Suppl 1, S152 - S241
A new probe illuminates endo-lysosomal Ca2+ measurements: A role for vesicular IP3 receptors?
Journal article
Morgan AJ., (2025), J Cell Biol, 224
Profiling glycosphingolipid changes in mouse and human cellular models of lysosomal free sialic acid storage disorder.
Journal article
Sabir MS. et al, (2025), Mol Genet Metab Rep, 45
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors.
Journal article
Calvo B. et al, (2025), J Cell Biol, 224
Association between gut microbiota and pediatric obesity: A systematic review
Journal article
Nóbrega R. et al, (2025), Nutrition, 140, 112875 - 112875
Correction: Glycoprotein non-metastatic melanoma protein B is a biomarker of inflammation in individuals with Gaucher disease: relationship to clinico-pathological subtypes.
Journal article
Kilavuz S. et al, (2025), Orphanet J Rare Dis, 20
Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex
Journal article
Hijazi SARA. et al, (2025), PLoS Biology
Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism.
Journal article
Sprigg C. et al, (2025), Biochem J, 482, 1627 - 1644
Elevated Acetylation of MFN2 is Accompanied by the Disruption of Mitochondrial Energy Metabolism and Inflammation in a Mouse Model of Depression.
Journal article
Xie X. et al, (2025), Mol Neurobiol, 62, 14167 - 14175
Plasma N-Glycan Profiling Enhances Diagnostic Precision in Multiple Sclerosis, AQP4-Ab NMOSD, and MOGAD.
Journal article
Kacerova T. et al, (2025), Neurol Neuroimmunol Neuroinflamm, 12
Period3 modulates the NAD+-SIRT3 axis to alleviate depression-like behaviour by enhancing NAMPT activity in mice.
Journal article
Xie X. et al, (2025), J Adv Res, 77, 309 - 320
Increased c-Fos immunoreactivity in anxiety-related brain regions following paroxetine discontinuation.
Journal article
Collins HM. et al, (2025), Neuropharmacology, 278
Physiological functions and pharmacological targeting of transient receptor potential channels.
Journal article
Chubanov V. et al, (2025), Pharmacol Rev, 77
Formic Acid Pretreatment Enhances Untargeted Serum and Plasma Metabolomics.
Journal article
Kacerova T. et al, (2025), Anal Chem, 97, 23014 - 23021
Glycoprotein non-metastatic melanoma protein B is a biomarker of inflammation in individuals with Gaucher disease: relationship to clinico-pathological subtypes.
Journal article
Kilavuz S. et al, (2025), Orphanet J Rare Dis, 20
Recent publications
Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis.
Journal article
de Almeida Miranda D. et al, (2026), Hippocampus, 36
Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.
Journal article
Kacerova T. et al, (2026), Commun Med (Lond)
Integrating NMR Metabolomics and Glycomics for Early Cancer Detection in Patients with Non-Specific Symptoms
Preprint
Kacerova T. et al, (2026)
Lesion level and severity acutely influence metabolomic profiles in spinal cord injury.
Journal article
Yates AG. et al, (2026), J Neuropathol Exp Neurol, 85, 24 - 38
The effects of elevated serum lactate on measures of apparent cerebral metabolism and perfusion in the anesthetised rodent brain
Preprint
Radford-Smith D. et al, (2025)
