Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Fei Guo

DPhil Student


A fundamental issue with population aging is the age-related gross and fine motor declines. It is recognized by now that the basal ganglia circuits are one of the most vulnerable to age-related effects. However, how these changes are regulated during aging remains unclear.

Recently, the Minichiello lab has established a unique mouse model that provides a rare example of age-dependent locomotor defect. They have demonstrated that loss of BDNF/TrkB signalling in striatopallidal neurons leads to age-dependent spontaneous hyperlocomotion, associated with reduced striatopallidal activation (Besusso D. et al, (2013), Nat Commun).

My project seeks to identify genes and pathways regulated by aging in a TrkB-dependent manner in striatopallidal neurons. We are doing this by combining state-of-the-art technologies including spatially restricted genetic manipulation, global gene expression analysis of specific neuronal populations (RNA-seq), smFISH, intracellular signalling and protein chemistry. The use of combinatorial state-of-the-art approaches will allow us first of all to understand basic molecular mechanisms regulating age-dependent locomotor activity and at the same time will open novel avenues to explore therapeutic interventions against loss of quality of life during aging.