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- Sharp Group | Neuropsychopharmacology Research Research Group
Senior postdoctoral researcher
- Lecturer in Medicine at Somerville College
The main focus of my work is on the influence of monoaminergic neurotransmitters like serotonin (5HT) and dopamine (DA) in relation to psychiatric diseases.
Currently in Trevor Sharp’s group, I am investigating electrical signals of 5HT neurons and cortical interneurons in the normal brain and during pharmacological inhibition of 5HT receptors in combination with neuroanatomical techniques.
Prior to this, I investigated how d-amino acid oxidase (DAO) influences midbrain DA physiology using electrophysiology, microdialysis and HPLC.
In Mark Ungless’s lab at Imperial College, I studied the functional diversity of dorsal raphe 5HT neurons using electrophysiology.
For my PhD with Wolfgang Hauber (University of Stuttgart), I investigated the involvement of the DA innervation of the anterior cingulate cortex on decision-making and learning. I have graduated from the University of Tübingen with an MSc in animal physiology, where I studied the role of the BNST on fear and anxiety behaviour with M. Fendt.
Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus.
Hescham S. et al, (2016), Brain Struct Funct, 221, 4281 - 4286
Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo.
Brouard JT. et al, (2015), ACS Chem Neurosci, 6, 1241 - 1247
Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo.
Schweimer JV. et al, (2014), Eur J Neurosci, 40, 2999 - 3009
D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.
Betts JF. et al, (2014), Front Synaptic Neurosci, 6
Genetic mouse models relevant to schizophrenia: taking stock and looking forward.
Harrison PJ. et al, (2012), Neuropharmacology, 62, 1164 - 1167