- Akerman Group Research Group
Postdoctoral Research Fellow
The main focus of my research lies in neural networks and synaptic computation. A fundamental question in neuroscience is how neural circuits utilise temporally and spatially patterned information in order to drive changes in synaptic connections.
Currently, I am studying the information transfer between different layers of cortex, using the mouse as an animal model. I use patch-clamp electrophysiology to dissect out synaptic communication between the different cortical layers, which are known to contain different types of neuron. Understanding the transfer of information across cortical layers will help us better understand the types of computation performed by cortex.
GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models.
Mahfooz K. et al, (2016), Neurobiol Dis, 93, 47 - 56
A Well-Defined Readily Releasable Pool with Fixed Capacity for Storing Vesicles at Calyx of Held.
Mahfooz K. et al, (2016), PLoS Comput Biol, 12
Levetiracetam accelerates the onset of supply rate depression in synaptic vesicle trafficking.
García-Pérez E. et al, (2015), Epilepsia, 56, 535 - 545
A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.
Gabriel T. et al, (2011), J Neurosci, 31, 11563 - 11577
Coordination between extrinsic extracellular matrix cues and intrinsic responses to orient the centrosome in polarizing cerebellar granule neurons.
Gupta SK. et al, (2010), J Neurosci, 30, 2755 - 2766