Contact information
Research groups
Colleges
Lora L. Martucci
BSc, MSc, PhD
Junior Research Fellow, New College
- Postdoctoral Fellow, Department of Pharmacology
Deciphering the role of TPCs in neuropeptide secretion
Biography
I obtained my PhD in 2021 from Paris Saclay University in France. During my years as a PhD student, I discovered that the TPCs (Two-Pore Channels) were involved in the secretion of the neurohormone oxytocin. A deletion of TPCs in mice result in very low oxytocin plasma levels along with altered social behaviour.
In 2021 I obtain a fellowship from the New College and I am now studying the signalling pathway of TPCs in neuropeptide release and deciphering the mechanisms underlying TPC involvement in oxytocin secretion.
Websites
Recent publications
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Low Temperature Delays the Effects of Ischemia in Bergmann Glia and in Cerebellar Tissue Swelling.
Journal article
Li X. et al, (2023), Biomedicines, 11
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Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.
Journal article
Martucci LL. et al, (2023), Proc Natl Acad Sci U S A, 120
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NAADP-Mediated Ca2+ Signalling.
Journal article
Galione A. et al, (2023), Handb Exp Pharmacol, 278, 3 - 34
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Two-pore channels: going with the flows.
Journal article
Morgan AJ. et al, (2022), Biochem Soc Trans, 50, 1143 - 1155
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Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores.
Journal article
Martucci LL. and Cancela J-M., (2022), Cell Calcium, 104