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Matthew Buchan

DPhil Student

  • Clarendon Scholar
  • MSc in Neuroscience
  • Graduate Rep - Medical Sciences Division

The mammalian cortex is characterised by specific patterns of synaptic connectivity which are thought to have enabled the development of complex brain processes. A fundamental question in neuroscience is how neurons establish such connections during brain development, thereby adopting unique functional identities within cortical networks.

A number of recent technical advances now make it possible to label specific populations of neurons in the brain at different stages of development, yielding exciting opportunities for the study of cortical development.   

Following from the observation that excitatory cortical neurons are generated from a heterogeneous pool of progenitor cells, I am using a combination of in vivo and in vitro electrophysiology, alongside a number of lineage labelling techniques to investigate the extent to which the functional identity of neurons in adult cortical networks is constrained as a function of the progenitor population from which they derive. 




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