MA(Oxon), MSc, PhD
Postdoctoral Research Assistant
I am interested in how the synapse (the junction between two neurons) is able to change its strength in response to a stimulus (plasticity). I’m especially interested in forms of plasticity where changes at one synapse can cause changes at neighbouring synapses on the same neuron. As well as being fascinating for its own sake, we hope that this work will help us to understand human memory better, which will ultimately assist the fight against diseases of memory (such as Alzheimer’s Disease).
To make progress in this work we need new imaging technologies. In collaboration with physicists at St Andrews University (the Dholakia group) and a photonics company in Glasgow (M Squared) I am developing light sheet microscopes of novel design which we hope will enable significant new advances in our understanding of synapse plasticity.
Fast volume-scanning light sheet microscopy reveals transient neuronal events.
Haslehurst P. et al, (2018), Biomed Opt Express, 9, 2154 - 2167
Rapid imaging of mammalian brain slices with a compact light sheet fluorescent microscope
Yang Z. et al, (2017), Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10051
An inverted light sheet microscope optimized for studies in neuroscience
Yang Z. et al, (2016), 2016 Conference on Lasers and Electro-Optics, CLEO 2016
A compact light-sheet microscope for the study of the mammalian central nervous system.
Yang Z. et al, (2016), Sci Rep, 6
Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis.
Paulin JJW. et al, (2016), Neural Plast, 2016