BA(hons), DPhil, FHEA
Postdoctoral Research Scientist
- Junior Research Fellow, Campion Hall
- Lecturer in Pharmacology, Magdalen College
Our research group, run by Dr Rebecca Burton and funded by the Wellcome Trust, aims to link together structural, signalling and patient information to improve our understanding of, and treatment options for, heart disease with a particular focus on the atria and sino-atrial node.
My research focusses on the control of calcium and electrical activity in cells of the heart. I am particularly interested in studying how calcium originating in lysosomes, which have traditionally been thought of as waste disposal units, contributes to acute and chronic signalling in health and disease. To do this I use a range of techniques including measuring the electrical and calcium activity from individual heart cells in real time, imaging the substructure of cardiac cells and assessing the proteome of tissue from healthy and diseased patients.
Outside of my laboratory research, I am involved with teaching undergraduate Medical/Biomedical Sciences and MSc Pharmacology students, and in Outreach activities. I passionately believe that Outreach is of central importance to improving uptake of and enthusiasm in the STEM disciplines and helping young people to realise and fulfil their potential. To this end, I work closely with schools, particularly in Hertfordshire, to conduct science days and careers talks and have also spoken as part of the international science festival Pint of Science.
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.
Aston D. et al, (2017), Sci Rep, 7
Mapping cardiac microstructure of rabbit heart in different mechanical states by high resolution diffusion tensor imaging: A proof-of-principle study.
Teh I. et al, (2016), Prog Biophys Mol Biol, 121, 85 - 96
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.
Capel RA. et al, (2015), J Biol Chem, 290, 30087 - 30098
CAN YOU TEACH AN OLD DOG NEW TRICKS? THE ANTIMALARIAL HYDROXYCHLOROQUINE SHOWS PROMISE IN CARDIAC RATE CONTROL THROUGH ACTIONS AT THE SINO-ATRIAL NODE
Capel RA. et al, (2015), HEART, 101, A2 - A2
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.
Capel RA. et al, (2015), Heart Rhythm, 12, 2186 - 2194