Rebecca M A Sitsapesan
Professor of Pharmacology
- Fellow in Medicine and Physiology, Hertford College
I hold a BSc in Pharmacology (Aberdeen), an MSc in Cardiovascular Studies (Leeds) and a PhD in Cardiac Physiology and Pharmacology (Strathclyde). My post-doctoral research into ion-channel biophysics began at the University of Glasgow and continued at the National Heart & Lung Institute at Imperial College, London.
In 1991, I was awarded a British Heart Foundation Basic Science Lectureship to investigate the function of cardiac intracellular Ca2+-release channels and a University Lectureship at Imperial College. I moved to Bristol in 2001 and was promoted to Professor of Pharmacology in 2011. In August 2013, I became Professor of Pharmacology at the University of Oxford.
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.
Venturi E. et al, (2018), Br J Pharmacol, 175, 938 - 952
Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.
Lin WK. et al, (2017), J Biol Chem, 292, 13243 - 13257
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.
El-Ajouz S. et al, (2017), J Physiol, 595, 4769 - 4784
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben M. et al, (2017), Nat Struct Mol Biol, 24, 114 - 122
Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signaling
Lin WK. et al, (2016), CARDIOVASCULAR RESEARCH, 111, S31 - S32