Ricardo Marquez Gomez
Newton International Fellow
Hello! I am conducting my postdoctoral research at Dr. Tommas Ellender’s Lab and I am from Chihuahua, Mexico (Yes, like the dog...it’s a real place).
I studied my PhD in Mexico City, focusing on the formation of G-protein coupled receptors (GPCRs) heterodimers in both cell lines and in native tissues. I was particularly interested in exploring the existence of a dimer between the histamine H3 and the adenosine A2A receptors, in the striatum. I did a short scholar visit at Purdue University, where I was able to demonstrate that the signaling pathway of the A2AR changes, after the formation of the A2A-H3 dimer in cell lines. Back at Mexico City, I demonstrated that the interaction also occurred in the rat striatum by using radioligand binding and co-immunoprecipitation assays. I didn't get to test the functional relevance of the dimer, which is part of the research I am conducting at Oxford.
For my postdoctoral project, we intend to explore how histamine is related to the development of the striatal patch and matrix compartments, as well as the participation of GPCRs heterodimers during cortico-striatal synaptogenesis. Since, the lack of histamine has been related to the appearance of tic-related disorders, the results obtained from this project may help us to understand the developmental etiology of these conditions.