Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Rudi Tong

DPhil Student

I am interested in the molecular mechanisms of synaptic plasticity. In particular, my research focuses on the mechanism of presynaptic long-term potentiation (LTP).

LTP is commonly studied due to its potential role in learning and memory. LTP can be expressed both pre- and postsynaptically. However, whereas postsynaptic LTP is well studied, little is known about the molecular mechanisms involved in presynaptic LTP.

I am currently looking at how the presynaptic terminal is able to detect the timing of pre- and postsynaptic activity, since timing is known to influence the decision between potentiation and depression of a synapse. I am focussing particularly on the nitric oxide-guanylate cyclase signalling pathway, which has been implicated in mediating presynaptic plasticity.