I am interested in the molecular mechanisms of synaptic plasticity. In particular, my research focuses on the mechanism of presynaptic long-term potentiation (LTP).
LTP is commonly studied due to its potential role in learning and memory. LTP can be expressed both pre- and postsynaptically. However, whereas postsynaptic LTP is well studied, little is known about the molecular mechanisms involved in presynaptic LTP.
I am currently looking at how the presynaptic terminal is able to detect the timing of pre- and postsynaptic activity, since timing is known to influence the decision between potentiation and depression of a synapse. I am focussing particularly on the nitric oxide-guanylate cyclase signalling pathway, which has been implicated in mediating presynaptic plasticity.