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- Akerman Group Research Group
Newton International Fellow
My scientific interests are focused on the chloride dynamics in different types of neuronal and glial cells, as well as in iPSCs. It is well known that chloride is a key player in many essential processes in living cells. Disturbances in chloride dynamics have been involved in a number of pathologies. Deciphering mechanisms underlying pathological changes in chloride dynamics might help in treating many diseases.
For monitoring chloride fluxes across cell membrane we have adopted a genetically-encoded probe, termed ClophensorN. This ratiometric probe consists of the Cl- and pH-sensitive protein EGFP and the reference fluorescent protein, tdTomatto, and can be targeted to specified cell types.