MRC Career Development Fellow
- University Research Lecturer
- Lecturer Corpus Christi College
My research focuses on the genetic and activity dependent rules that govern the development of the basal ganglia. My group combines electrophysiological recordings of multiple neurons in vitro and in vivo in combination with optogenetic and pharmacogenetic techniques to both observe and manipulate neural activity and circuit development.
Key research areas:
• Development of the striatal neural circuitry.
• Neuromodulation of striatal circuit function.
• Cellular mechanisms underlying the generation of physiological and pathological neural network activity
Our current research efforts are focused on defining the early developmental processes controlling the formation of the striatum, with the aim of generating rationale and identifying targets for intervention in a range of basal ganglia neurodevelopmental disorders.
A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space.
Trouche S. et al, (2019), Cell
Sleep and Serotonin Modulate Paracapsular Nitric Oxide Synthase Expressing Neurons of the Amygdala.
Bocchio M. et al, (2016), eNeuro, 3
Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges.
Ellender TJ. et al, (2014), J Neurosci, 34, 15208 - 15222
The thalamostriatal system in normal and diseased states.
Smith Y. et al, (2014), Front Syst Neurosci, 8
Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum
Ellender TJ. et al, (2013), Journal of Physiology, 591, 257 - 272
Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission.
Raimondo JV. et al, (2012), Nat Neurosci, 15, 1102 - 1104
Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine.
Ellender TJ. et al, (2011), J Neurosci, 31, 15340 - 15351