Research groups
Colleges
Trevor Sharp
BSc, PhD
Professor of Neuropharmacology
- Radcliffe Medical Fellow in Neuroscience, University College Oxford
- Lecturer in Pharmacology, Corpus Christi College Oxford
I graduated in Biochemistry at the University of Birmingham in 1979, and established my interest in neuropharmacology of CNS transmitters in the Department of Physiology and Pharmacology at the University of Nottingham where I obtained my PhD in 1983. I spent the next three years in the Department of Pharmacology at the Karolinska Institute, Stockholm with Urban Ungerstedt as a SERC and Karolinska Institute Overseas Fellow.
In 1986 I joined the MRC Unit of Clinical Pharmacology in Oxford, and was appointed to the MRC External Scientific Staff in 1993. I then joined the Department of Pharmacology in Oxford at the start of the new millennium. Throughout my time in Oxford, my research has focused on the pharmacology and physiology of monoamine transmitters, particularly in relation to the treatment and cause of psychiatric disorder. I hold visiting Professorships with the Universities of Maastricht and Hokkaido. I am currently the Vice-President (Europe) of the International Society for Serotonin Research (ISSR). I was awarded the Irvine Page Lectureship by the ISSR in 2016.
Key publications
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High-frequency stimulation of the subthalamic nucleus modulates neuronal activity in the lateral habenula nucleus.
Journal article
Hartung H. et al, (2016), Eur J Neurosci, 44, 2698 - 2707
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Serotonin, Amygdala and Fear: Assembling the Puzzle.
Journal article
Bocchio M. et al, (2016), Front Neural Circuits, 10
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Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Journal article
Masaki C. et al, (2016), Psychopharmacology (Berl), 233, 2655 - 2661
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Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala.
Journal article
Bocchio M. et al, (2015), Neuropsychopharmacology, 40, 3015 - 3026
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Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo.
Journal article
Brouard JT. et al, (2015), ACS Chem Neurosci, 6, 1241 - 1247
Recent publications
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Rebound activation of 5-HT neurons following SSRI discontinuation.
Journal article
Collins HM. et al, (2024), Neuropsychopharmacology
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Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms.
Journal article
Gullino LS. et al, (2024), ACS Chem Neurosci
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In Vivo Two-Photon Microscopy Reveals Sensory-Evoked Serotonin (5-HT) Release in Adult Mammalian Neocortex.
Journal article
Ocana-Santero G. et al, (2024), ACS Chem Neurosci