Postdoctoral Research Assistant
I am interested in the mechanisms regulating arterial contractility and dilation. Vascular tone plays an important role in the regulation of blood flow and blood pressure in normal physiology and in a number of diseases including hypertension, diabetes and ischaemic diseases. My current research focuses on how calcium signalling in small arteries can control blood vessel diameter.
Recently, I have described how alternative splicing of VEGF-A can regulate blood vessel formation and affect the progression of infantile haemangioma, the most common neoplasm of infancy. I am now investigating how VEGF-A, which is elevated in a number of pathological conditions, can contribute to endothelial dysfunction and vascular diseases
Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice.
Lemmey HAL. et al, (2018), Vascul Pharmacol
The kindlin-2 double act.
Ye X. and Dora KA., (2017), J Physiol, 595
Voltage-dependent Ca2+entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles.
Garland CJ. et al, (2017), Sci Signal, 10
Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma
Ye X. et al, (2016), The Journal of Pathology, 239, 139 - 151
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Hamdollah Zadeh MA. et al, (2015), Mol Oncol, 9, 167 - 178