BSc, PhD, MRSC
My research focuses on the design, synthesis and chemical biological study of small molecules that play important roles in regulating cellular function and metabolism. In the past I have worked on small molecule inhibitors of enzymes that regulate corticosteroids metabolism within cells, which may potentially be used to develop new drugs for the treatment of metabolic related disorders. I have also worked in the discovery of new generation of antimicrobial molecules that showed inhibiting activity against drug resistant bacterial.
My current research work focuses on the synthesis of analogues of adenophostin A, which is potent agonist of inositol triphosphate (IP3) receptor. These molecules are crucial in Calcium ion signalling process within cells and play key roles on different cellular functions.
An update on 2,5-diketopiperazines from marine organisms.
Huang R-M. et al, (2014), Mar Drugs, 12, 6213 - 6235
Marine nucleosides: structure, bioactivity, synthesis and biosynthesis.
Huang R-M. et al, (2014), Mar Drugs, 12, 5817 - 5838
Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Su X. et al, (2012), Bioorg Med Chem, 20, 6394 - 6402
Synthesis and evaluation of thiadiazole derivatives as inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Pradaux-Caggiano F. et al, (2012), MedChemComm, 3, 1117 - 1124
Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1.
Su X. et al, (2011), ChemMedChem, 6, 1616 - 1629